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LY 255283

CAS No. 117690-79-6

LY 255283( —— )

Catalog No. M22528 CAS No. 117690-79-6

LY 255283 is a specific antagonit of leukotriene B4 (LTB4) receptor.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    LY 255283
  • Note
    Research use only, not for human use.
  • Brief Description
    LY 255283 is a specific antagonit of leukotriene B4 (LTB4) receptor.
  • Description
    LY 255283 is a specific antagonit of leukotriene B4 (LTB4) receptor. It inhibits the production of LTB(4) in human peripheral blood polymorphonuclear leukocytes (PMNL) and in monocytes activated by calcium ionophore A23187.All seven rats given only the vehicle died within 2 h of reperfusion, whereas rats treated with LY-255283 (3 or 10 mg/kg iv), a leukotriene B4 (LTB4) receptor antagonist given 10 min before reperfusion, exhibited significantly higher survival rates of 57% (4 out of 7) and 75% (6 out of 8), respectively, 2 h after reperfusion.?Rats given 1 mg/kg of LY-255283 showed no significant improvement in survival.?Splanchnic artery occlusion (SAO)-shock rats treated with LY-255283 (3 or 10 mg/kg) exhibited significantly attenuated accumulation of plasma free amino-nitrogenous compounds and of a myocardial depressant factor.?Treatment with LY-255283 (10 mg/kg) markedly (P less than 0.01) ameliorated the deficits of endothelium-dependent relaxation of isolated superior mesenteric artery (SMA) rings in untreated SAO-shock rats.?LY-255283 at 10 mg/kg significantly attenuated the increased myeloperoxidase activity in the intestinal tissue of SAO-shock rats.
  • In Vitro
    Cell Viability Assay Cell Line:253 J-BV cells.Concentration:5 or 10 μM.Incubation Time:7 days.Result:Inhibition of BLT2 signaling attenuates aggressive migration by 253 J-BV cells.
  • In Vivo
    Animal Model:Mice (253 J-BV cells injected).Dosage:2.5 mg/kg.Administration:IP injected 3 and 5 days after injection of cells. Result:By 12 weeks after injection, in mice treated with LY255283 only 0-3 nodules formed per lung, and histological analysis confirmed that the number of micrometastatic lesions was markedly reduced.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Leukotriene Receptor
  • Recptor
    BLT2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    117690-79-6
  • Formula Weight
    360.46
  • Molecular Formula
    C19H28N4O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (277.43 mM)
  • SMILES
    CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Karasawa A , Guo J P , Ma X L , et al. Protective actions of a leukotriene B4 antagonist in splanchnic ischemia and reperfusion in rats.[J]. Am J Physiol, 1991, 261(2):191-8.
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